While every person’s experience with eczema is unique, there are defining moments in everyone's journey–from realizing the need for relief from symptoms, to advocating for yourself and finding a treatment that’s right for you. Listen to the following people talk about their reviews and experience with OPZELURA, along with their OPZELURA moment.
Emily, a sonographer from New Jersey, spent a lifetime struggling with her eczema. Having watched her mother and grandmother have flare-ups from the condition, Emily knew she had to find relief. When her daughter refused to hold her hand during a flare-up, her journey to find relief brought her to OPZELURA. What a relief.*
*Individual results may vary. OPZELURA is not for everyone.
(DESCRIPTION)
Name super builds onto black screen while soft background music begins to play.
(ON-SCREEN TEXT)
EMILY
(DESCRIPTION)
Emily steps into the frame and speaks directly to the camera. The view is zoomed in, with only her shoulders and up showing.
(ON-SCREEN TEXT)
This video is brought to you by Incyte. Emily was compensated for her participation.
(SPEECH)
Emily: Hi, my name is Emily and I'm from New Jersey. I’m married with three wonderful children.
(DESCRIPTION)
Camera zooms out to show a full-body view of Emily standing while talking to the camera on an empty, dark set.
(SPEECH)
Emily: I work in a hospital performing high risk ultrasounds, and I have mild to moderate eczema.
(DESCRIPTION)
Bedroom set of a young girl comes in behind Emily and Emily sits on the end of the bed. The comforter is a pale shade of pink and a stuffed elephant sits next to the bed. Three panels behind the bed show delicate artwork and wallpaper with gold details. Stage crew members dressed in black can be seen setting up the scene and then exiting from view.
(SPEECH)
Emily: My earliest memory of having eczema was when I was nine or 10 years old.
(DESCRIPTION)
Photo of Emily as a young girl sitting on her mother’s lap while in a kiddy pool outside shows on screen as Emily continues to share her story.
(SPEECH)
Emily: I remember playing outside and…
(DESCRIPTION)
View switches back to Emily sitting in her childhood bedroom. Camera alternates between a zoomed-in view of her head and shoulders and a panned-out view of her full body.
(SPEECH)
Emily: …getting this uncontrollable itch on the arch of my foot. I was scratching so hard, but nothing was making the itch go away. I would wake up in the middle of the night because the itching was so intense and I couldn't sleep through it. At that point, my grandmother was like, "We need to take you to the dermatologist," and that's when I was diagnosed with mild to moderate eczema.
(DESCRIPTION)
Emily stands up from the bed and walks off the scene of her childhood bedroom to one of a baby’s nursery.
(SPEECH)
Emily: As I got older, my eczema began to change. In my 20s, my husband and…
(DESCRIPTION)
Crew members dressed in black can be seen moving a crib into the scene. The camera focuses on a crew member placing a white, fluffy teddy bear on the area rug of the baby’s nursery. Emily stands in front of the crib, positioned in front of a window. An armchair and floor lamp complete the room. Camera alternates between full-screen and zoomed-in view of Emily as she talks.
(SPEECH)
Emily: …I started IVF and I noticed my eczema becoming worse. It was keeping me up at night from scratching, and that's when I decided to go back to the dermatologist to see if maybe there was something more I could be doing. My experience at the dermatologist was more steroids. Maybe it was time to start an injectable, but an injectable wasn't right for me.
(DESCRIPTION)
Photo of Emily smiling with her baby sleeping on her chest shows on screen. View switches back to Emily standing in the nursery.
(SPEECH)
Emily: The itch was just so incredible that even my sheets touching my skin just made me scratch more.
(DESCRIPTION)
Crew members in black begin removing furniture from the baby’s nursery.
(SPEECH)
Emily: A standout moment for me living with eczema happened on my daughter's soccer field.
(DESCRIPTION)
Emily exits the scene of the nursery, with crew members setting the scene for a soccer field. Emily crosses the field to sit on a metal bench along the side of the field.
(SPEECH)
Emily: I was at my daughter Samantha's soccer game and she was finally participating. She went to score her first goal and she made it. I was so proud I ran onto the field. When I went to high five her, one of her little teammates said, "Ew, what's on your hand?"
(DESCRIPTION)
Photo of the palms of Emily’s hand with eczema irritation shows on screen. View returns to Emily sitting on the bench.
(SPEECH)
Emily: It completely stopped the moment and I had to kneel down and explain what my eczema was on my hand. We had waited for this moment for so long and I wanted to celebrate her, and instead it took the whole important moment for my daughter completely away from her. I think eczema took a lot of special moments away from me as a mom. I clearly remember going to cross the street and my daughter wouldn't hold my hand. I realized it was from my eczema because when I went to reach for her, even when we were just watching a movie, she said, "I don't want to touch that." I was devastated. All I want to do is snuggle with my children, and now they were trying to stay away from my eczema.
(DESCRIPTION)
Emily stands up from the bench and begins to walk off the field. She exits the scene of the soccer field and enters the scene of a hospital room.
(SPEECH)
Emily: The turning point in my journey was when my co-workers at the hospital started to notice my eczema. They even started to try to help me.
(DESCRIPTION)
Emily stands in the center of the hospital room, speaking to the camera. Views alternate between zoomed-in and full body.
(SPEECH)
Emily: One day, one of the physicians came in and said, "Did you hear about a cream called OPZELURA that is steroid-free? You really have got to try it."
(ON-SCREEN TEXT)
OPZELURA® (ruxolitinib) cream 1.5% is a treatment for mild to moderate eczema. For short-term, non-continuous treatment in people 12 and older without weakened immune systems and not well controlled on topical Rx therapies or when therapies are not recommended.
(SPEECH)
Emily: I kind of brushed it off because I felt like I had hit a brick wall and this was something that I was just going to have to live with.
(ON-SCREEN TEXT)
The use of OPZELURA along with therapeutic biologics, other JAK inhibitors, or strong immunosuppressants such as azathioprine or cyclosporine is not recommended.
(DESCRIPTION)
The camera focuses on an armchair in the hospital room with a pillow and blanket on it, then zooms in on Emily’s waist with her thumb hanging from the front pocket of her jeans.
(SPEECH)
Narrator: OPZELURA can lower your ability to fight infections. Tell your doctor if you have or had an infection, TB, hepatitis B or C, blood clots in your legs or lungs, heart attack, stroke, cancer, high cholesterol, are a smoker, or pregnant.
(ON-SCREEN TEXT)
OPZELURA can lower your ability to fight infections.
Tell your doctor if you have or had an infection, TB, hepatitis B or C, blood clots in your legs or lungs, heart attack, stroke, cancer, high cholesterol, are a smoker, or pregnant.
(DESCRIPTION)
The camera focuses on a zoomed-in view of a soccer ball on a field with a car wheel in the background.
(SPEECH)
Narrator: OPZELURA may cause serious lung infections, certain cancers, immune system problems, blood clots, and low blood cell counts. Major cardiovascular events or death occurred in those 50+ taking oral JAK inhibitors.
(ON-SCREEN TEXT)
OPZELURA may cause serious lung infections, certain cancers, immune system problems, blood clots, and low blood cell counts. Major cardiovascular events or death occurred in those 50+ taking oral JAK inhibitors.
(DESCRIPTION)
The camera focuses on the area between the scenes of Emily’s childhood bedroom and the baby’s nursery.
(SPEECH)
Narrator: The most common side effect was the common cold.
(ON-SCREEN TEXT)
The most common side effect was the common cold.
(DESCRIPTION)
Emily returns to the frame, speaking to the camera from the hospital room.
(SPEECH)
Emily: Finally, I did. I called the dermatologist. I got right in,...
(ON-SCREEN TEXT)
For topical use only. Do not use in your eyes, mouth, or vagina. Apply twice daily as directed.
(SPEECH)
Emily: …and we decided that OPZELURA was the right treatment for me. I really like that I don't have to wean off of it because I'm a busy mom…
(ON-SCREEN TEXT)
Apply a thin layer of OPZELURA cream twice daily to affected areas. Use OPZELURA on up to 20% of your body as directed by your healthcare provider.
(SPEECH)
Emily: …and I can just stop the cream. As soon as I have a flare up, I can start it again. I just apply it once in the morning, once at night. It's really simple.
(ON-SCREEN TEXT)
Stop using OPZELURA when your signs and symptoms of atopic dermatitis, such as itching, rash, and redness go away, or as directed by your healthcare provider. Do not use more than one 60-gram tube per week.
(SPEECH)
Emily: The moment I realized OPZELURA was working was around day four, and even my children started to notice. My husband noticed, coworkers noticed I wasn't scratching.
(ON-SCREEN TEXT)
Individual results may vary. In a medical study of mild to moderate atopic dermatitis, 54% of patients had clear to almost clear skin at 8 weeks and 52% of patients had a significant reduction in their itch, compared to 15% of patients who used a cream that did not contain medication.
(SPEECH)
Emily: I was paying attention. I was present because I wasn't thinking about that itch in the back of my mind. Every morning, my daughters would check…
(ON-SCREEN TEXT)
Tell your healthcare provider if your symptoms do not improve within 8 weeks of treatment. Results may vary.
(SPEECH)
Emily: …and see the progress and say, "Mommy, look, it's going away," and the best moment of all…
(ON-SCREEN TEXT)
Before starting OPZELURA, tell your doctor if you have an infection, are being treated for one, have TB or have been in close contact with someone with TB; or had Hepatitis B or C.
(SPEECH)
Emily: …is when we curled up on the couch and watched a movie and they wanted to hold my hand again.
(DESCRIPTION)
Photo of Emily and her 3 daughters sitting closely at an airport gate shows on screen, followed by another photo of Emily and one of her daughters holding hands. Then, the view returns to Emily speaking in the hospital room.
(SPEECH)
Emily: My advice to anyone with eczema is to not give up. You need to call your dermatologist and find out if OPZELURA is right for you.
(ON-SCREEN TEXT)
Your doctor should check for infections before and during treatment. Tell your doctor if you had blood clots in your legs or lungs. OPZELURA may cause low platelets, low red and white blood cell counts. Keep watching for Important Safety Information.
(DESCRIPTION)
Screen fills to a dark purple background with the OPZELURA logo and important safety information and indication scrolling.
(SPEECH AND ON-SCREEN TEXT)
Narrator:
OPZELURA is a prescription medicine used on the skin (topical) for the short-term and non-continuous chronic treatment of mild to moderate eczema (atopic dermatitis) in non-immunocompromised adults and children 12 years of age and older whose disease is not well controlled with topical prescription therapies or when those therapies are not recommended.
The use of OPZELURA along with therapeutic biologics, other JAK inhibitors, or strong immunosuppressants such as azathioprine or cyclosporine is not recommended.
It is not known if OPZELURA is safe and effective in children less than 12 years of age with atopic dermatitis.
OPZELURA is for use on the skin only. Do not use OPZELURA in your eyes, mouth, or vagina.
OPZELURA may cause serious side effects, including:
Serious Infections: OPZELURA contains ruxolitinib. Ruxolitinib belongs to a class of medicines called Janus kinase (JAK) inhibitors. JAK inhibitors are medicines that affect your immune system. JAK inhibitors can lower the ability of your immune system to fight infections. Some people have had serious infections while taking JAK inhibitors by mouth, including tuberculosis (TB), and infections caused by bacteria, fungi, or viruses that can spread throughout the body. Some people have been hospitalized or died from these infections. Some people have had serious infections of their lungs while taking OPZELURA. Your healthcare provider should watch you closely for signs and symptoms of TB during treatment with OPZELURA.
OPZELURA should not be used in people with an active, serious infection, including localized infections. You should not start using OPZELURA if you have any kind of infection unless your healthcare provider tells you it is okay. You may be at a higher risk of developing shingles (herpes zoster) while using OPZELURA.
Increased risk of death due to any reason (all causes): Increased risk of death has happened in people 50 years of age and older who have at least 1 heart disease (cardiovascular) risk factor and are taking a medicine in the class of medicines called JAK inhibitors by mouth.
Cancer and immune system problems: OPZELURA may increase your risk of certain cancers by changing the way your immune system works. Lymphoma and other cancers have happened in people taking a medicine in the class of medicines called JAK inhibitors by mouth. People taking JAK inhibitors by mouth have a higher risk of certain cancers including lymphoma and lung cancer, especially if they are a current or past smoker. Some people have had skin cancers while using OPZELURA. Your healthcare provider will regularly check your skin during your treatment with OPZELURA. Limit the amount of time you spend in the sunlight. Wear protective clothing when you are in the sun and use a broad-spectrum sunscreen.
Increased risk of major cardiovascular events: Increased risk of major cardiovascular events such as heart attack, stroke, or death have happened in people 50 years of age and older who have at least 1 heart disease (cardiovascular) risk factor and taking a medicine in the class of medicines called JAK inhibitors by mouth, especially in current or past smokers.
Blood clots: Blood clots in the veins of your legs (deep vein thrombosis, DVT) or lungs (pulmonary embolism, PE) can happen in some people taking OPZELURA. This may be life-threatening. Blood clots in the vein of the legs (deep vein thrombosis, DVT) and lungs (pulmonary embolism, PE) have happened more often in people who are 50 years of age and older and with at least 1 heart disease (cardiovascular) risk factor taking a medicine in the class of medicines called JAK inhibitors by mouth.
Low blood cell counts: OPZELURA may cause low platelet counts (thrombocytopenia), low red blood cell counts (anemia), and low white blood cell counts (neutropenia). If needed, your healthcare provider will do a blood test to check your blood cell counts during your treatment with OPZELURA and may stop your treatment if signs or symptoms of low blood cell counts happen.
Cholesterol increases: Cholesterol increase has happened in people when ruxolitinib is taken by mouth. Tell your healthcare provider if you have high cholesterol or triglycerides.
Before starting OPZELURA, tell your healthcare provider if you:
After starting OPZELURA:
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
The most common side effects of OPZELURA in people treated for atopic dermatitis include: common cold (nasopharyngitis), diarrhea, bronchitis, ear infection, increase in a type of white blood cell (eosinophil) count, hives, inflamed hair pores (folliculitis), swelling of the tonsils (tonsillitis), and runny nose (rhinorrhea).
These are not all of the possible side effects of OPZELURA. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to Incyte Corporation at 1-855-463-3463.
Please see the Full Prescribing Information, including Boxed Warning, and Medication Guide for OPZELURA.
[END OF TRANSCRIPT]
Emily, a sonographer from New Jersey, spent a lifetime struggling with her eczema. Having watched her mother and grandmother have flare-ups from the condition, Emily knew she had to find relief. When her daughter refused to hold her hand during a flare-up, her journey to find relief brought her to OPZELURA. What a relief.*
*Individual results may vary. OPZELURA is not for everyone.
(DESCRIPTION)
Name super builds onto black screen while soft background music begins to play.
(ON-SCREEN TEXT)
EMILY
(DESCRIPTION)
Emily steps into the frame and speaks directly to the camera. The view is zoomed in, with only her shoulders and up showing.
(ON-SCREEN TEXT)
This video is brought to you by Incyte. Emily was compensated for her participation.
(SPEECH)
Emily: Hi, my name is Emily and I'm from New Jersey. I’m married with three wonderful children.
(DESCRIPTION)
Camera zooms out to show a full-body view of Emily standing while talking to the camera on an empty, dark set.
(SPEECH)
Emily: I work in a hospital performing high risk ultrasounds, and I have mild to moderate eczema.
(DESCRIPTION)
Bedroom set of a young girl comes in behind Emily and Emily sits on the end of the bed. The comforter is a pale shade of pink and a stuffed elephant sits next to the bed. Three panels behind the bed show delicate artwork and wallpaper with gold details. Stage crew members dressed in black can be seen setting up the scene and then exiting from view.
(SPEECH)
Emily: My earliest memory of having eczema was when I was nine or 10 years old.
(DESCRIPTION)
Photo of Emily as a young girl sitting on her mother’s lap while in a kiddy pool outside shows on screen as Emily continues to share her story.
(SPEECH)
Emily: I remember playing outside and…
(DESCRIPTION)
View switches back to Emily sitting in her childhood bedroom. Camera alternates between a zoomed-in view of her head and shoulders and a panned-out view of her full body.
(SPEECH)
Emily: …getting this uncontrollable itch on the arch of my foot. I was scratching so hard, but nothing was making the itch go away. I would wake up in the middle of the night because the itching was so intense and I couldn't sleep through it. At that point, my grandmother was like, "We need to take you to the dermatologist," and that's when I was diagnosed with mild to moderate eczema.
(DESCRIPTION)
Emily stands up from the bed and walks off the scene of her childhood bedroom to one of a baby’s nursery.
(SPEECH)
Emily: As I got older, my eczema began to change. In my 20s, my husband and…
(DESCRIPTION)
Crew members dressed in black can be seen moving a crib into the scene. The camera focuses on a crew member placing a white, fluffy teddy bear on the area rug of the baby’s nursery. Emily stands in front of the crib, positioned in front of a window. An armchair and floor lamp complete the room. Camera alternates between full-screen and zoomed-in view of Emily as she talks.
(SPEECH)
Emily: …I started IVF and I noticed my eczema becoming worse. It was keeping me up at night from scratching, and that's when I decided to go back to the dermatologist to see if maybe there was something more I could be doing. My experience at the dermatologist was more steroids. Maybe it was time to start an injectable, but an injectable wasn't right for me.
(DESCRIPTION)
Photo of Emily smiling with her baby sleeping on her chest shows on screen. View switches back to Emily standing in the nursery.
(SPEECH)
Emily: The itch was just so incredible that even my sheets touching my skin just made me scratch more.
(DESCRIPTION)
Crew members in black begin removing furniture from the baby’s nursery.
(SPEECH)
Emily: A standout moment for me living with eczema happened on my daughter's soccer field.
(DESCRIPTION)
Emily exits the scene of the nursery, with crew members setting the scene for a soccer field. Emily crosses the field to sit on a metal bench along the side of the field.
(SPEECH)
Emily: I was at my daughter Samantha's soccer game and she was finally participating. She went to score her first goal and she made it. I was so proud I ran onto the field. When I went to high five her, one of her little teammates said, "Ew, what's on your hand?"
(DESCRIPTION)
Photo of the palms of Emily’s hand with eczema irritation shows on screen. View returns to Emily sitting on the bench.
(SPEECH)
Emily: It completely stopped the moment and I had to kneel down and explain what my eczema was on my hand. We had waited for this moment for so long and I wanted to celebrate her, and instead it took the whole important moment for my daughter completely away from her. I think eczema took a lot of special moments away from me as a mom. I clearly remember going to cross the street and my daughter wouldn't hold my hand. I realized it was from my eczema because when I went to reach for her, even when we were just watching a movie, she said, "I don't want to touch that." I was devastated. All I want to do is snuggle with my children, and now they were trying to stay away from my eczema.
(DESCRIPTION)
Emily stands up from the bench and begins to walk off the field. She exits the scene of the soccer field and enters the scene of a hospital room.
(SPEECH)
Emily: The turning point in my journey was when my co-workers at the hospital started to notice my eczema. They even started to try to help me.
(DESCRIPTION)
Emily stands in the center of the hospital room, speaking to the camera. Views alternate between zoomed-in and full body.
(SPEECH)
Emily: One day, one of the physicians came in and said, "Did you hear about a cream called OPZELURA that is steroid-free? You really have got to try it."
(ON-SCREEN TEXT)
OPZELURA® (ruxolitinib) cream 1.5% is a treatment for mild to moderate eczema. For short-term, non-continuous treatment in people 12 and older without weakened immune systems and not well controlled on topical Rx therapies or when therapies are not recommended.
(SPEECH)
Emily: I kind of brushed it off because I felt like I had hit a brick wall and this was something that I was just going to have to live with.
(ON-SCREEN TEXT)
The use of OPZELURA along with therapeutic biologics, other JAK inhibitors, or strong immunosuppressants such as azathioprine or cyclosporine is not recommended.
(DESCRIPTION)
The camera focuses on an armchair in the hospital room with a pillow and blanket on it, then zooms in on Emily’s waist with her thumb hanging from the front pocket of her jeans.
(SPEECH)
Narrator: OPZELURA can lower your ability to fight infections. Tell your doctor if you have or had an infection, TB, hepatitis B or C, blood clots in your legs or lungs, heart attack, stroke, cancer, high cholesterol, are a smoker, or pregnant.
(ON-SCREEN TEXT)
OPZELURA can lower your ability to fight infections.
Tell your doctor if you have or had an infection, TB, hepatitis B or C, blood clots in your legs or lungs, heart attack, stroke, cancer, high cholesterol, are a smoker, or pregnant.
(DESCRIPTION)
The camera focuses on a zoomed-in view of a soccer ball on a field with a car wheel in the background.
(SPEECH)
Narrator: OPZELURA may cause serious lung infections, certain cancers, immune system problems, blood clots, and low blood cell counts. Major cardiovascular events or death occurred in those 50+ taking oral JAK inhibitors.
(ON-SCREEN TEXT)
OPZELURA may cause serious lung infections, certain cancers, immune system problems, blood clots, and low blood cell counts. Major cardiovascular events or death occurred in those 50+ taking oral JAK inhibitors.
(DESCRIPTION)
The camera focuses on the area between the scenes of Emily’s childhood bedroom and the baby’s nursery.
(SPEECH)
Narrator: The most common side effect was the common cold.
(ON-SCREEN TEXT)
The most common side effect was the common cold.
(DESCRIPTION)
Emily returns to the frame, speaking to the camera from the hospital room.
(SPEECH)
Emily: Finally, I did. I called the dermatologist. I got right in,...
(ON-SCREEN TEXT)
For topical use only. Do not use in your eyes, mouth, or vagina. Apply twice daily as directed.
(SPEECH)
Emily: …and we decided that OPZELURA was the right treatment for me. I really like that I don't have to wean off of it because I'm a busy mom…
(ON-SCREEN TEXT)
Apply a thin layer of OPZELURA cream twice daily to affected areas. Use OPZELURA on up to 20% of your body as directed by your healthcare provider.
(SPEECH)
Emily: …and I can just stop the cream. As soon as I have a flare up, I can start it again. I just apply it once in the morning, once at night. It's really simple.
(ON-SCREEN TEXT)
Stop using OPZELURA when your signs and symptoms of atopic dermatitis, such as itching, rash, and redness go away, or as directed by your healthcare provider. Do not use more than one 60-gram tube per week.
(SPEECH)
Emily: The moment I realized OPZELURA was working was around day four, and even my children started to notice. My husband noticed, coworkers noticed I wasn't scratching.
(ON-SCREEN TEXT)
Individual results may vary. In a medical study of mild to moderate atopic dermatitis, 54% of patients had clear to almost clear skin at 8 weeks and 52% of patients had a significant reduction in their itch, compared to 15% of patients who used a cream that did not contain medication.
(SPEECH)
Emily: I was paying attention. I was present because I wasn't thinking about that itch in the back of my mind. Every morning, my daughters would check…
(ON-SCREEN TEXT)
Tell your healthcare provider if your symptoms do not improve within 8 weeks of treatment. Results may vary.
(SPEECH)
Emily: …and see the progress and say, "Mommy, look, it's going away," and the best moment of all…
(ON-SCREEN TEXT)
Before starting OPZELURA, tell your doctor if you have an infection, are being treated for one, have TB or have been in close contact with someone with TB; or had Hepatitis B or C.
(SPEECH)
Emily: …is when we curled up on the couch and watched a movie and they wanted to hold my hand again.
(DESCRIPTION)
Photo of Emily and her 3 daughters sitting closely at an airport gate shows on screen, followed by another photo of Emily and one of her daughters holding hands. Then, the view returns to Emily speaking in the hospital room.
(SPEECH)
Emily: My advice to anyone with eczema is to not give up. You need to call your dermatologist and find out if OPZELURA is right for you.
(ON-SCREEN TEXT)
Your doctor should check for infections before and during treatment. Tell your doctor if you had blood clots in your legs or lungs. OPZELURA may cause low platelets, low red and white blood cell counts. Keep watching for Important Safety Information.
(DESCRIPTION)
Screen fills to a dark purple background with the OPZELURA logo and important safety information and indication scrolling.
(SPEECH AND ON-SCREEN TEXT)
Narrator:
OPZELURA is a prescription medicine used on the skin (topical) for the short-term and non-continuous chronic treatment of mild to moderate eczema (atopic dermatitis) in non-immunocompromised adults and children 12 years of age and older whose disease is not well controlled with topical prescription therapies or when those therapies are not recommended.
The use of OPZELURA along with therapeutic biologics, other JAK inhibitors, or strong immunosuppressants such as azathioprine or cyclosporine is not recommended.
It is not known if OPZELURA is safe and effective in children less than 12 years of age with atopic dermatitis.
OPZELURA is for use on the skin only. Do not use OPZELURA in your eyes, mouth, or vagina.
OPZELURA may cause serious side effects, including:
Serious Infections: OPZELURA contains ruxolitinib. Ruxolitinib belongs to a class of medicines called Janus kinase (JAK) inhibitors. JAK inhibitors are medicines that affect your immune system. JAK inhibitors can lower the ability of your immune system to fight infections. Some people have had serious infections while taking JAK inhibitors by mouth, including tuberculosis (TB), and infections caused by bacteria, fungi, or viruses that can spread throughout the body. Some people have been hospitalized or died from these infections. Some people have had serious infections of their lungs while taking OPZELURA. Your healthcare provider should watch you closely for signs and symptoms of TB during treatment with OPZELURA.
OPZELURA should not be used in people with an active, serious infection, including localized infections. You should not start using OPZELURA if you have any kind of infection unless your healthcare provider tells you it is okay. You may be at a higher risk of developing shingles (herpes zoster) while using OPZELURA.
Increased risk of death due to any reason (all causes): Increased risk of death has happened in people 50 years of age and older who have at least 1 heart disease (cardiovascular) risk factor and are taking a medicine in the class of medicines called JAK inhibitors by mouth.
Cancer and immune system problems: OPZELURA may increase your risk of certain cancers by changing the way your immune system works. Lymphoma and other cancers have happened in people taking a medicine in the class of medicines called JAK inhibitors by mouth. People taking JAK inhibitors by mouth have a higher risk of certain cancers including lymphoma and lung cancer, especially if they are a current or past smoker. Some people have had skin cancers while using OPZELURA. Your healthcare provider will regularly check your skin during your treatment with OPZELURA. Limit the amount of time you spend in the sunlight. Wear protective clothing when you are in the sun and use a broad-spectrum sunscreen.
Increased risk of major cardiovascular events: Increased risk of major cardiovascular events such as heart attack, stroke, or death have happened in people 50 years of age and older who have at least 1 heart disease (cardiovascular) risk factor and taking a medicine in the class of medicines called JAK inhibitors by mouth, especially in current or past smokers.
Blood clots: Blood clots in the veins of your legs (deep vein thrombosis, DVT) or lungs (pulmonary embolism, PE) can happen in some people taking OPZELURA. This may be life-threatening. Blood clots in the vein of the legs (deep vein thrombosis, DVT) and lungs (pulmonary embolism, PE) have happened more often in people who are 50 years of age and older and with at least 1 heart disease (cardiovascular) risk factor taking a medicine in the class of medicines called JAK inhibitors by mouth.
Low blood cell counts: OPZELURA may cause low platelet counts (thrombocytopenia), low red blood cell counts (anemia), and low white blood cell counts (neutropenia). If needed, your healthcare provider will do a blood test to check your blood cell counts during your treatment with OPZELURA and may stop your treatment if signs or symptoms of low blood cell counts happen.
Cholesterol increases: Cholesterol increase has happened in people when ruxolitinib is taken by mouth. Tell your healthcare provider if you have high cholesterol or triglycerides.
Before starting OPZELURA, tell your healthcare provider if you:
After starting OPZELURA:
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
The most common side effects of OPZELURA in people treated for atopic dermatitis include: common cold (nasopharyngitis), diarrhea, bronchitis, ear infection, increase in a type of white blood cell (eosinophil) count, hives, inflamed hair pores (folliculitis), swelling of the tonsils (tonsillitis), and runny nose (rhinorrhea).
These are not all of the possible side effects of OPZELURA. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to Incyte Corporation at 1-855-463-3463.
Please see the Full Prescribing Information, including Boxed Warning, and Medication Guide for OPZELURA.
[END OF TRANSCRIPT]
Listen to Dr. Lee, a board-certified dermatologist, talk about her experience as both a doctor and patient living with eczema from a young age. The flare-ups that affected her during medical school help her better empathize with her fellow patients.*
*Individual results may vary. OPZELURA is not for everyone. Dr. Lee was compensated for her participation.
(DESCRIPTION)
Name super builds onto black screen while footsteps can be heard.
(ON-SCREEN TEXT)
DR. LEE
(DESCRIPTION)
Dr. Lee steps into the frame, covering her name and speaking directly to the camera. The view is zoomed in, with only her shoulders and up showing.
(SPEECH)
Dr. Lee: Hello, I'm Dr. Sandra Lee. I'm a board-certified dermatologist.
(ON-SCREEN TEXT)
This video is brought to you by Incyte. Dr. Lee was compensated for her participation.
(DESCRIPTION)
Camera zooms out to show a full-body view of Dr. Lee standing, while talking to the camera on an empty, dark set.
(SPEECH)
Dr. Lee: You may know me well as Dr. Pimple Popper, but what you may not know is that I have mild-to-moderate eczema. I had eczema ever since I was a newborn. It was very itchy. It was very uncomfortable. I had to wear mittens…
(DESCRIPTION)
Photos of Dr. Lee as a young girl show on screen: first wearing overalls and holding a bowl, then wearing a “Happy Birthday” tiara and talking on a rotary phone, and lastly sitting on an armchair in a living room.
(SPEECH)
Dr. Lee: …to sort of block my fingernails from really scratching at my skin. And when I became a tween,...
(DESCRIPTION)
View switches back to Dr. Lee standing with a black background. Camera alternates between a zoomed-in view of her head and shoulders and a panned-out view of her full body.
(SPEECH)
Dr. Lee: …I had this rash that was really distinctive and very itchy. It made me not want to show my skin very much, because it was something that I didn't want people to know that I had, and it made me feel different.
(DESCRIPTION)
Camera cuts to zoomed-in view of Dr. Lee. Then, the camera zooms out to reveal she is now sitting in the scene of a college dormitory room. As she speaks, crew members dressed in black add furniture, a space heater, and books to her dorm room.
(SPEECH)
Dr. Lee: I decided to go to medical school because it was my destiny, really. My dad's a dermatologist. My mom's a nurse. It was really exciting to go away to school too and to be in a new place. This dorm room reminds me a lot of how I lived back in medical school. When I moved from the West Coast to the East Coast,...
(DESCRIPTION)
Photos of Dr. Lee when she was younger show on screen: first standing in her dorm room with an adult, then standing in a hallway wearing her white medical coat.
(SPEECH)
Dr. Lee: …that environment change really wreaked havoc on my skin.
(DESCRIPTION)
Camera view returns to Dr. Lee sitting in the dorm room scene.
(SPEECH)
Dr. Lee: The stress in medical school certainly made things worse, but I was really getting my eczema flares in new areas now. I had one of the worst flares during medical school. I was studying for an exam, and it was cold, so I decided to use this dusty old space heater, a lot like this one here, and I turned it on close to my face. Big mistake, because it triggered a flare, and I just immediately could feel that heat and that dust on my face just working with my skin to cause it to get really tingly. I remember turning that thing off as soon as I started feeling those symptoms and just slathering myself in moisturizer to try to slow this down, because I knew that this was potentially going to be bad. I think I just learned as I got older, exposed to more things, exposed to more environments you know that, "Okay, this makes sense that this might trigger something for me." Or you sort of learn through trial and error, really. You'll be exposed to a new situation and go, "Oh, this is not for me."
(DESCRIPTION)
Dr. Lee stands up from the chair and walks off the scene of her dorm room. She exits through a doorway and onto the scene of the backstage area of a television set. Crew members dressed in black can be seen moving clothing racks and a chair into place. Dr. Lee sits down in the chair next to a vanity mirror and table and continues talking.
(SPEECH)
Dr. Lee: As Dr. Pimple Popper, I'm on camera all the time. If I knew that I was going to be on camera the next day and I felt a flare coming on,...
(DESCRIPTION)
Photo of Dr. Lee filming while on her mobile phone shows briefly, then returns to the backstage area scene.
(SPEECH)
Dr. Lee: …that would be very concerning to me. I avoid trigger factors on a daily basis. I mean, there are certain clothes that I would avoid, like some of that.
(DESCRIPTION)
Dr. Lee points to the clothing rack and motions with her hand to show dislike of the clothing option.
(SPEECH)
Dr. Lee: Like that itchy gray wool thing; no, that's not happening. Eczema can affect my day any day, and it's no different when I'm on set or not.
(DESCRIPTION)
Crew members remove the clothing rack as well as the vanity and mirror. Dr. Lee gets up from her chair and the crew members remove that as well. Crew members flip the wall to reveal an office scene, with framed certificates and bookshelves on the wall.
(SPEECH)
Dr. Lee: Eczema has helped me to relate to my patients better, because I think it increases my compassion and my ability to connect with them if I'm going through the same things that they're going through. Every now and then I'll get a flare of eczema in my armpits, and I don't love to use a topical steroid in that area.
(DESCRIPTION)
Zoomed-out view of Dr. Lee now shows her standing in an office scene with a desk, coat hanger, and additional furniture.
(SPEECH)
Dr. Lee: I was really excited to try OPZELURA because it is a non-steroidal, it's a topical, and I can use it as monotherapy.
(ON-SCREEN TEXT)
OPZELURA® (ruxolitinib) cream 1.5% is a treatment for mild to moderate eczema. For short-term, non-continuous treatment in people 12 and older without weakened immune systems and not well controlled on topical Rx therapies or when therapies are not recommended.
(SPEECH)
Dr. Lee: When something is monotherapy, that means that I can use it alone. I don't have to worry about other products or using it in conjunction with other treatments.
(ON-SCREEN TEXT)
The use of OPZELURA along with therapeutic biologics, other JAK inhibitors, or strong immunosuppressants such as azathioprine or cyclosporine is not recommended. For topical use only. Do not use in your eyes, mouth, or vagina. Apply twice daily as directed.
(DESCRIPTION)
Camera focuses on white coat hanging from coat rack, with framed certificates in the background.
(SPEECH)
Narrator: OPZELURA can lower your ability to fight infections.
(ON-SCREEN TEXT)
OPZELURA can lower your ability to fight infections.
(DESCRIPTION)
Camera switches to focus on Dr. Lee’s hands clasped in her lap.
(SPEECH)
Narrator: Tell your doctor if you have or had an infection, TB, hepatitis B or C, blood clots in your legs or lungs, heart attack, stroke, cancer, high cholesterol, are a smoker, or pregnant.
(ON-SCREEN TEXT)
Tell your doctor if you have or had an infection, TB, hepatitis B or C, blood clots in your legs or lungs, heart attack, stroke, cancer, high cholesterol, are a smoker, or pregnant.
(DESCRIPTION)
Camera switches to an illuminated “ON THE AIR” sign from the backstage scene room.
(SPEECH)
Narrator: OPZELURA may cause serious lung infections, certain cancers, immune system problems, blood clots, and low blood cell counts. Major cardiovascular events or death occurred in those 50+ taking oral JAK inhibitors.
(ON-SCREEN TEXT)
OPZELURA may cause serious lung infections, certain cancers, immune system problems, blood clots, and low blood cell counts. Major cardiovascular events or death occurred in those 50+ taking oral JAK inhibitors.
(DESCRIPTION)
Camera switches to a close-up view of an OPZELURA tube sitting on Dr. Lee’s desk next to a mug filled with pens.
(SPEECH)
Narrator: The most common side effect was the common cold.
(ON-SCREEN TEXT)
The most common side effect was the common cold.
(DESCRIPTION)
Camera returns to Dr. Lee speaking in her office scene. The camera alternates between zoomed-in and zoomed-out views. Dr. Lee moves her arms for emphasis.
(SPEECH)
Dr. Lee: You can use OPZELURA on up to 20% of your body, and you can use it for sensitive areas too; and…
(ON-SCREEN TEXT)
Apply a thin layer of OPZELURA cream twice daily to affected areas as directed by your healthcare provider. OPZELURA is for use on the skin only. Do not use in your eyes, mouth, or vagina.
(SPEECH)
Dr. Lee: …it's just a twice-a-day topical treatment. And you can use it when you have a flare of eczema, and once that flare clears, you can stop.
(ON-SCREEN TEXT)
Stop using OPZELURA when your signs and symptoms of atopic dermatitis, such as itching, rash, and redness go away, or as directed by your healthcare provider. Do not use more than one 60-gram tube per week.
(SPEECH)
Dr. Lee: What's really nice about OPZELURA is it works pretty quickly too... at least for me. When I had an itch and I used OPZELURA for a few days, I really noticed an improvement in my itch and I noticed a clearing in my flare within a few weeks. If you're curious about OPZELURA,…
(ON-SCREEN TEXT)
Individual results may vary. In a medical study of mild to moderate atopic dermatitis, 54% of patients had clear to almost clear skin at 8 weeks and 52% of patients had a significant reduction in their itch, compared to 15% of patients who used a cream that did not contain medication.
(SPEECH)
Dr. Lee: …talk to your healthcare provider about the benefits and risks and see whether OPZELURA is for you.
(ON-SCREEN TEXT)
Tell your healthcare provider if your symptoms do not improve within 8 weeks of treatment. Results may vary. Keep watching for Important Safety Information.
(DESCRIPTION)
Screen fills to a dark purple background with the OPZELURA logo and important safety information and indication starts scrolling.
(SPEECH AND ON-SCREEN TEXT)
Narrator:
OPZELURA is a prescription medicine used on the skin (topical) for the short-term and non-continuous chronic treatment of mild to moderate eczema (atopic dermatitis) in non-immunocompromised adults and children 12 years of age and older whose disease is not well controlled with topical prescription therapies or when those therapies are not recommended.
The use of OPZELURA along with therapeutic biologics, other JAK inhibitors, or strong immunosuppressants such as azathioprine or cyclosporine is not recommended.
It is not known if OPZELURA is safe and effective in children less than 12 years of age with atopic dermatitis.
OPZELURA is for use on the skin only. Do not use OPZELURA in your eyes, mouth, or vagina.
OPZELURA may cause serious side effects, including:
Serious Infections: OPZELURA contains ruxolitinib. Ruxolitinib belongs to a class of medicines called Janus kinase (JAK) inhibitors. JAK inhibitors are medicines that affect your immune system. JAK inhibitors can lower the ability of your immune system to fight infections. Some people have had serious infections while taking JAK inhibitors by mouth, including tuberculosis (TB) and infections caused by bacteria, fungi, or viruses that can spread throughout the body. Some people have been hospitalized or died from these infections. Some people have had serious infections of their lungs while taking OPZELURA. Your healthcare provider should watch you closely for signs and symptoms of TB during treatment with OPZELURA.
OPZELURA should not be used in people with an active, serious infection, including localized infections. You should not start using OPZELURA if you have any kind of infection unless your healthcare provider tells you it is okay. You may be at a higher risk of developing shingles (herpes zoster) while using OPZELURA.
Increased risk of death due to any reason (all causes): Increased risk of death has happened in people 50 years of age and older who have at least 1 heart disease (cardiovascular) risk factor and are taking a medicine in the class of medicines called JAK inhibitors by mouth.
Cancer and immune system problems: OPZELURA may increase your risk of certain cancers by changing the way your immune system works. Lymphoma and other cancers have happened in people taking a medicine in the class of medicines called JAK inhibitors by mouth. People taking JAK inhibitors by mouth have a higher risk of certain cancers including lymphoma and lung cancer, especially if they are a current or past smoker. Some people have had skin cancers while using OPZELURA. Your healthcare provider will regularly check your skin during your treatment with OPZELURA. Limit the amount of time you spend in the sunlight. Wear protective clothing when you are in the sun and use a broad-spectrum sunscreen.
Increased risk of major cardiovascular events: Increased risk of major cardiovascular events such as heart attack, stroke, or death have happened in people 50 years of age and older who have at least 1 heart disease (cardiovascular) risk factor and taking a medicine in the class of medicines called JAK inhibitors by mouth, especially in current or past smokers.
Blood clots: Blood clots in the veins of your legs (deep vein thrombosis, DVT) or lungs (pulmonary embolism, PE) can happen in some people taking OPZELURA. This may be life-threatening. Blood clots in the vein of the legs (deep vein thrombosis, DVT) and lungs (pulmonary embolism, PE) have happened more often in people who are 50 years of age and older and with at least 1 heart disease (cardiovascular) risk factor taking a medicine in the class of medicines called JAK inhibitors by mouth.
Low blood cell counts: OPZELURA may cause low platelet counts (thrombocytopenia), low red blood cell counts (anemia), and low white blood cell counts (neutropenia). If needed, your healthcare provider will do a blood test to check your blood cell counts during your treatment with OPZELURA and may stop your treatment if signs or symptoms of low blood cell counts happen.
Cholesterol increases: Cholesterol increase has happened in people when ruxolitinib is taken by mouth. Tell your healthcare provider if you have high cholesterol or triglycerides.
Before starting OPZELURA, tell your healthcare provider if you:
After starting OPZELURA:
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
The most common side effects of OPZELURA in people treated for atopic dermatitis include: common cold (nasopharyngitis), diarrhea, bronchitis, ear infection, increase in a type of white blood cell (eosinophil) count, hives, inflamed hair pores (folliculitis), swelling of the tonsils (tonsillitis), and runny nose (rhinorrhea).
These are not all of the possible side effects of OPZELURA. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to Incyte Corporation at 1-855-463-3463.
Please see the Full Prescribing Information, including Boxed Warning, and Medication Guide for OPZELURA.
[END OF TRANSCRIPT]
Listen to Dr. Lee, a board-certified dermatologist, talk about her experience as both a doctor and patient living with eczema from a young age. The flare-ups that affected her during medical school help her better empathize with her fellow patients.*
*Individual results may vary. OPZELURA is not for everyone. Dr. Lee was compensated for her participation.
(DESCRIPTION)
Name super builds onto black screen while footsteps can be heard.
(ON-SCREEN TEXT)
DR. LEE
(DESCRIPTION)
Dr. Lee steps into the frame, covering her name and speaking directly to the camera. The view is zoomed in, with only her shoulders and up showing.
(SPEECH)
Dr. Lee: Hello, I'm Dr. Sandra Lee. I'm a board-certified dermatologist.
(ON-SCREEN TEXT)
This video is brought to you by Incyte. Dr. Lee was compensated for her participation.
(DESCRIPTION)
Camera zooms out to show a full-body view of Dr. Lee standing, while talking to the camera on an empty, dark set.
(SPEECH)
Dr. Lee: You may know me well as Dr. Pimple Popper, but what you may not know is that I have mild-to-moderate eczema. I had eczema ever since I was a newborn. It was very itchy. It was very uncomfortable. I had to wear mittens…
(DESCRIPTION)
Photos of Dr. Lee as a young girl show on screen: first wearing overalls and holding a bowl, then wearing a “Happy Birthday” tiara and talking on a rotary phone, and lastly sitting on an armchair in a living room.
(SPEECH)
Dr. Lee: …to sort of block my fingernails from really scratching at my skin. And when I became a tween,...
(DESCRIPTION)
View switches back to Dr. Lee standing with a black background. Camera alternates between a zoomed-in view of her head and shoulders and a panned-out view of her full body.
(SPEECH)
Dr. Lee: …I had this rash that was really distinctive and very itchy. It made me not want to show my skin very much, because it was something that I didn't want people to know that I had, and it made me feel different.
(DESCRIPTION)
Camera cuts to zoomed-in view of Dr. Lee. Then, the camera zooms out to reveal she is now sitting in the scene of a college dormitory room. As she speaks, crew members dressed in black add furniture, a space heater, and books to her dorm room.
(SPEECH)
Dr. Lee: I decided to go to medical school because it was my destiny, really. My dad's a dermatologist. My mom's a nurse. It was really exciting to go away to school too and to be in a new place. This dorm room reminds me a lot of how I lived back in medical school. When I moved from the West Coast to the East Coast,...
(DESCRIPTION)
Photos of Dr. Lee when she was younger show on screen: first standing in her dorm room with an adult, then standing in a hallway wearing her white medical coat.
(SPEECH)
Dr. Lee: …that environment change really wreaked havoc on my skin.
(DESCRIPTION)
Camera view returns to Dr. Lee sitting in the dorm room scene.
(SPEECH)
Dr. Lee: The stress in medical school certainly made things worse, but I was really getting my eczema flares in new areas now. I had one of the worst flares during medical school. I was studying for an exam, and it was cold, so I decided to use this dusty old space heater, a lot like this one here, and I turned it on close to my face. Big mistake, because it triggered a flare, and I just immediately could feel that heat and that dust on my face just working with my skin to cause it to get really tingly. I remember turning that thing off as soon as I started feeling those symptoms and just slathering myself in moisturizer to try to slow this down, because I knew that this was potentially going to be bad. I think I just learned as I got older, exposed to more things, exposed to more environments you know that, "Okay, this makes sense that this might trigger something for me." Or you sort of learn through trial and error, really. You'll be exposed to a new situation and go, "Oh, this is not for me."
(DESCRIPTION)
Dr. Lee stands up from the chair and walks off the scene of her dorm room. She exits through a doorway and onto the scene of the backstage area of a television set. Crew members dressed in black can be seen moving clothing racks and a chair into place. Dr. Lee sits down in the chair next to a vanity mirror and table and continues talking.
(SPEECH)
Dr. Lee: As Dr. Pimple Popper, I'm on camera all the time. If I knew that I was going to be on camera the next day and I felt a flare coming on,...
(DESCRIPTION)
Photo of Dr. Lee filming while on her mobile phone shows briefly, then returns to the backstage area scene.
(SPEECH)
Dr. Lee: …that would be very concerning to me. I avoid trigger factors on a daily basis. I mean, there are certain clothes that I would avoid, like some of that.
(DESCRIPTION)
Dr. Lee points to the clothing rack and motions with her hand to show dislike of the clothing option.
(SPEECH)
Dr. Lee: Like that itchy gray wool thing; no, that's not happening. Eczema can affect my day any day, and it's no different when I'm on set or not.
(DESCRIPTION)
Crew members remove the clothing rack as well as the vanity and mirror. Dr. Lee gets up from her chair and the crew members remove that as well. Crew members flip the wall to reveal an office scene, with framed certificates and bookshelves on the wall.
(SPEECH)
Dr. Lee: Eczema has helped me to relate to my patients better, because I think it increases my compassion and my ability to connect with them if I'm going through the same things that they're going through. Every now and then I'll get a flare of eczema in my armpits, and I don't love to use a topical steroid in that area.
(DESCRIPTION)
Zoomed-out view of Dr. Lee now shows her standing in an office scene with a desk, coat hanger, and additional furniture.
(SPEECH)
Dr. Lee: I was really excited to try OPZELURA because it is a non-steroidal, it's a topical, and I can use it as monotherapy.
(ON-SCREEN TEXT)
OPZELURA® (ruxolitinib) cream 1.5% is a treatment for mild to moderate eczema. For short-term, non-continuous treatment in people 12 and older without weakened immune systems and not well controlled on topical Rx therapies or when therapies are not recommended.
(SPEECH)
Dr. Lee: When something is monotherapy, that means that I can use it alone. I don't have to worry about other products or using it in conjunction with other treatments.
(ON-SCREEN TEXT)
The use of OPZELURA along with therapeutic biologics, other JAK inhibitors, or strong immunosuppressants such as azathioprine or cyclosporine is not recommended. For topical use only. Do not use in your eyes, mouth, or vagina. Apply twice daily as directed.
(DESCRIPTION)
Camera focuses on white coat hanging from coat rack, with framed certificates in the background.
(SPEECH)
Narrator: OPZELURA can lower your ability to fight infections.
(ON-SCREEN TEXT)
OPZELURA can lower your ability to fight infections.
(DESCRIPTION)
Camera switches to focus on Dr. Lee’s hands clasped in her lap.
(SPEECH)
Narrator: Tell your doctor if you have or had an infection, TB, hepatitis B or C, blood clots in your legs or lungs, heart attack, stroke, cancer, high cholesterol, are a smoker, or pregnant.
(ON-SCREEN TEXT)
Tell your doctor if you have or had an infection, TB, hepatitis B or C, blood clots in your legs or lungs, heart attack, stroke, cancer, high cholesterol, are a smoker, or pregnant.
(DESCRIPTION)
Camera switches to an illuminated “ON THE AIR” sign from the backstage scene room.
(SPEECH)
Narrator: OPZELURA may cause serious lung infections, certain cancers, immune system problems, blood clots, and low blood cell counts. Major cardiovascular events or death occurred in those 50+ taking oral JAK inhibitors.
(ON-SCREEN TEXT)
OPZELURA may cause serious lung infections, certain cancers, immune system problems, blood clots, and low blood cell counts. Major cardiovascular events or death occurred in those 50+ taking oral JAK inhibitors.
(DESCRIPTION)
Camera switches to a close-up view of an OPZELURA tube sitting on Dr. Lee’s desk next to a mug filled with pens.
(SPEECH)
Narrator: The most common side effect was the common cold.
(ON-SCREEN TEXT)
The most common side effect was the common cold.
(DESCRIPTION)
Camera returns to Dr. Lee speaking in her office scene. The camera alternates between zoomed-in and zoomed-out views. Dr. Lee moves her arms for emphasis.
(SPEECH)
Dr. Lee: You can use OPZELURA on up to 20% of your body, and you can use it for sensitive areas too; and…
(ON-SCREEN TEXT)
Apply a thin layer of OPZELURA cream twice daily to affected areas as directed by your healthcare provider. OPZELURA is for use on the skin only. Do not use in your eyes, mouth, or vagina.
(SPEECH)
Dr. Lee: …it's just a twice-a-day topical treatment. And you can use it when you have a flare of eczema, and once that flare clears, you can stop.
(ON-SCREEN TEXT)
Stop using OPZELURA when your signs and symptoms of atopic dermatitis, such as itching, rash, and redness go away, or as directed by your healthcare provider. Do not use more than one 60-gram tube per week.
(SPEECH)
Dr. Lee: What's really nice about OPZELURA is it works pretty quickly too... at least for me. When I had an itch and I used OPZELURA for a few days, I really noticed an improvement in my itch and I noticed a clearing in my flare within a few weeks. If you're curious about OPZELURA,…
(ON-SCREEN TEXT)
Individual results may vary. In a medical study of mild to moderate atopic dermatitis, 54% of patients had clear to almost clear skin at 8 weeks and 52% of patients had a significant reduction in their itch, compared to 15% of patients who used a cream that did not contain medication.
(SPEECH)
Dr. Lee: …talk to your healthcare provider about the benefits and risks and see whether OPZELURA is for you.
(ON-SCREEN TEXT)
Tell your healthcare provider if your symptoms do not improve within 8 weeks of treatment. Results may vary. Keep watching for Important Safety Information.
(DESCRIPTION)
Screen fills to a dark purple background with the OPZELURA logo and important safety information and indication starts scrolling.
(SPEECH AND ON-SCREEN TEXT)
Narrator:
OPZELURA is a prescription medicine used on the skin (topical) for the short-term and non-continuous chronic treatment of mild to moderate eczema (atopic dermatitis) in non-immunocompromised adults and children 12 years of age and older whose disease is not well controlled with topical prescription therapies or when those therapies are not recommended.
The use of OPZELURA along with therapeutic biologics, other JAK inhibitors, or strong immunosuppressants such as azathioprine or cyclosporine is not recommended.
It is not known if OPZELURA is safe and effective in children less than 12 years of age with atopic dermatitis.
OPZELURA is for use on the skin only. Do not use OPZELURA in your eyes, mouth, or vagina.
OPZELURA may cause serious side effects, including:
Serious Infections: OPZELURA contains ruxolitinib. Ruxolitinib belongs to a class of medicines called Janus kinase (JAK) inhibitors. JAK inhibitors are medicines that affect your immune system. JAK inhibitors can lower the ability of your immune system to fight infections. Some people have had serious infections while taking JAK inhibitors by mouth, including tuberculosis (TB) and infections caused by bacteria, fungi, or viruses that can spread throughout the body. Some people have been hospitalized or died from these infections. Some people have had serious infections of their lungs while taking OPZELURA. Your healthcare provider should watch you closely for signs and symptoms of TB during treatment with OPZELURA.
OPZELURA should not be used in people with an active, serious infection, including localized infections. You should not start using OPZELURA if you have any kind of infection unless your healthcare provider tells you it is okay. You may be at a higher risk of developing shingles (herpes zoster) while using OPZELURA.
Increased risk of death due to any reason (all causes): Increased risk of death has happened in people 50 years of age and older who have at least 1 heart disease (cardiovascular) risk factor and are taking a medicine in the class of medicines called JAK inhibitors by mouth.
Cancer and immune system problems: OPZELURA may increase your risk of certain cancers by changing the way your immune system works. Lymphoma and other cancers have happened in people taking a medicine in the class of medicines called JAK inhibitors by mouth. People taking JAK inhibitors by mouth have a higher risk of certain cancers including lymphoma and lung cancer, especially if they are a current or past smoker. Some people have had skin cancers while using OPZELURA. Your healthcare provider will regularly check your skin during your treatment with OPZELURA. Limit the amount of time you spend in the sunlight. Wear protective clothing when you are in the sun and use a broad-spectrum sunscreen.
Increased risk of major cardiovascular events: Increased risk of major cardiovascular events such as heart attack, stroke, or death have happened in people 50 years of age and older who have at least 1 heart disease (cardiovascular) risk factor and taking a medicine in the class of medicines called JAK inhibitors by mouth, especially in current or past smokers.
Blood clots: Blood clots in the veins of your legs (deep vein thrombosis, DVT) or lungs (pulmonary embolism, PE) can happen in some people taking OPZELURA. This may be life-threatening. Blood clots in the vein of the legs (deep vein thrombosis, DVT) and lungs (pulmonary embolism, PE) have happened more often in people who are 50 years of age and older and with at least 1 heart disease (cardiovascular) risk factor taking a medicine in the class of medicines called JAK inhibitors by mouth.
Low blood cell counts: OPZELURA may cause low platelet counts (thrombocytopenia), low red blood cell counts (anemia), and low white blood cell counts (neutropenia). If needed, your healthcare provider will do a blood test to check your blood cell counts during your treatment with OPZELURA and may stop your treatment if signs or symptoms of low blood cell counts happen.
Cholesterol increases: Cholesterol increase has happened in people when ruxolitinib is taken by mouth. Tell your healthcare provider if you have high cholesterol or triglycerides.
Before starting OPZELURA, tell your healthcare provider if you:
After starting OPZELURA:
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
The most common side effects of OPZELURA in people treated for atopic dermatitis include: common cold (nasopharyngitis), diarrhea, bronchitis, ear infection, increase in a type of white blood cell (eosinophil) count, hives, inflamed hair pores (folliculitis), swelling of the tonsils (tonsillitis), and runny nose (rhinorrhea).
These are not all of the possible side effects of OPZELURA. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to Incyte Corporation at 1-855-463-3463.
Please see the Full Prescribing Information, including Boxed Warning, and Medication Guide for OPZELURA.
[END OF TRANSCRIPT]
Anna meets Mandy Moore, who both share the connection of living with eczema. Hear about the moment Anna and her mom, Rachael, realized it was time to find relief, and how OPZELURA helped do just that.
With help from her mother Rachael, Anna found relief from her eczema symptoms. Learn how Rachael advocated for her daughter.
Eric first experienced eczema symptoms while in his 50's, where the itch and inflammation bothered him daily. Hear how Eric sought relief from his symptoms.
For as long as he could remember, Cameron struggled with his eczema. Watch as Cameron and his mother, Jen, open up about relief with OPZELURA.
Taryn still remembers her kindergarten classmates refusing to play with her because of her eczema. Watch as she and her mother, Lynde, speak about OPZELURA and the relief that followed.
Individual results may vary. OPZELURA is not for everyone.
• Angela, OPZELURA patient*
• Louis, OPZELURA patient*
• Adrienne, OPZELURA patient*
• Taryn, OPZELURA patient*
*Individual results may vary. OPZELURA is not for everyone.
Tell us about the moment you decided to find relief from your symptoms and how it changed your experience living with eczema.
OPZELURA is a prescription medicine used on the skin (topical) for the short-term and non-continuous chronic treatment of mild to moderate eczema (atopic dermatitis) in non-immunocompromised adults and children 12 years of age and older whose disease is not well controlled with topical prescription therapies or when those therapies are not recommended.
The use of OPZELURA along with therapeutic biologics, other JAK inhibitors, or strong immunosuppressants such as azathioprine or cyclosporine is not recommended.
It is not known if OPZELURA is safe and effective in children less than 12 years of age with atopic dermatitis.
OPZELURA is for use on the skin only. Do not use OPZELURA in your eyes, mouth, or vagina.
OPZELURA may cause serious side effects, including:
Serious Infections: OPZELURA contains ruxolitinib. Ruxolitinib belongs to a class of medicines called Janus kinase (JAK) inhibitors. JAK inhibitors are medicines that affect your immune system. JAK inhibitors can lower the ability of your immune system to fight infections. Some people have had serious infections while taking JAK inhibitors by mouth, including tuberculosis (TB), and infections caused by bacteria, fungi, or viruses that can spread throughout the body. Some people have been hospitalized or died from these infections. Some people have had serious infections of their lungs while taking OPZELURA. Your healthcare provider should watch you closely for signs and symptoms of TB during treatment with OPZELURA.
OPZELURA should not be used in people with an active, serious infection, including localized infections. You should not start using OPZELURA if you have any kind of infection unless your healthcare provider tells you it is okay. You may be at a higher risk of developing shingles (herpes zoster) while using OPZELURA.
Increased risk of death due to any reason (all causes): Increased risk of death has happened in people 50 years of age and older who have at least 1 heart disease (cardiovascular) risk factor and are taking a medicine in the class of medicines called JAK inhibitors by mouth.
Cancer and immune system problems: OPZELURA may increase your risk of certain cancers by changing the way your immune system works. Lymphoma and other cancers have happened in people taking a medicine in the class of medicines called JAK inhibitors by mouth. People taking JAK inhibitors by mouth have a higher risk of certain cancers including lymphoma and lung cancer, especially if they are a current or past smoker. Some people have had skin cancers while using OPZELURA. Your healthcare provider will regularly check your skin during your treatment with OPZELURA. Limit the amount of time you spend in the sunlight. Wear protective clothing when you are in the sun and use a broad-spectrum sunscreen.
Increased risk of major cardiovascular events: Increased risk of major cardiovascular events such as heart attack, stroke, or death have happened in people 50 years of age and older who have at least 1 heart disease (cardiovascular) risk factor and taking a medicine in the class of medicines called JAK inhibitors by mouth, especially in current or past smokers.
Blood clots: Blood clots in the veins of your legs (deep vein thrombosis, DVT) or lungs (pulmonary embolism, PE) can happen in some people taking OPZELURA. This may be life-threatening. Blood clots in the vein of the legs (deep vein thrombosis, DVT) and lungs (pulmonary embolism, PE) have happened more often in people who are 50 years of age and older and with at least 1 heart disease (cardiovascular) risk factor taking a medicine in the class of medicines called JAK inhibitors by mouth.
Low blood cell counts: OPZELURA may cause low platelet counts (thrombocytopenia), low red blood cell counts (anemia), and low white blood cell counts (neutropenia). If needed, your healthcare provider will do a blood test to check your blood cell counts during your treatment with OPZELURA and may stop your treatment if signs or symptoms of low blood cell counts happen.
Cholesterol increases: Cholesterol increase has happened in people when ruxolitinib is taken by mouth. Tell your healthcare provider if you have high cholesterol or triglycerides.
Before starting OPZELURA, tell your healthcare provider if you:
After starting OPZELURA:
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
The most common side effects of OPZELURA in people treated for atopic dermatitis include: common cold (nasopharyngitis), diarrhea, bronchitis, ear infection, increase in a type of white blood cell (eosinophil) count, hives, inflamed hair pores (folliculitis), swelling of the tonsils (tonsillitis), and runny nose (rhinorrhea).
These are not all of the possible side effects of OPZELURA. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to Incyte Corporation at 1-855-463-3463.
Please see the Full Prescribing Information, including Boxed Warning, and Medication Guide for OPZELURA.
